PMCA

PMCA increases dopaminergic neuron survival in fly cells.

“In primary neuronal cultures, PMCA downregulation reduced dopaminergic neuron survival and induced transient increases in neurite branching.”

Cellsshown by PMCA downregulationprimary dopaminergic neuron culture

“Plasma Membrane Calcium ATPase Downregulation in Dopaminergic Neurons Induces Presynaptic Dysfunction and Neuronal Vulnerability In Vivo and In Vitro”

bioRxiv (Cold Spring Harbor Laboratory)·May 5, 2026Preprint

PMCA has no effect on synaptic active zone structure in flies.

“Notably, the synaptic active zone structure was preserved, indicating primarily functional rather than structural alterations.”

Model organismsPMCA downregulationdopaminergic neuron

“Plasma Membrane Calcium ATPase Downregulation in Dopaminergic Neurons Induces Presynaptic Dysfunction and Neuronal Vulnerability In Vivo and In Vitro”

bioRxiv (Cold Spring Harbor Laboratory)·May 5, 2026Preprint

PMCA shortens lifespan in flies.

“TH-Gal4>PMCARNAi flies died earlier compared to controls”

Model organismsdriven by TH-Gal4

Downregulation of Plasma Membrane Ca²⁺ ATPase driven by tyrosine hydroxylase-Gal4 reduces Drosophila lifespan independently of effects in neurons

Fly·Mar 23, 2023