OTUB2

There are 2 papers on OTUB2 in aging research: none in people yet, 1 in animals, 1 in cells. The newest story, Oct 29, 2026: “Blocking a protein reduced nerve cell degeneration in mice”.

Gene

2 papers study it3 findings

HGNCNCBI GeneTaxon

1 new paper in 30 daysSee all 2

None of its findings points the other way.

  • 2 independent labs in 2 countries
  • Funders: Japan Society for the Promotion of Science and 1 more
  • Animals1
  • Cells1

Effects

3

Neurodegeneration

upin mice1

1 study
  1. OTUB2 increases neurodegeneration in mice (Shown by genetic deletion in ALS and aged mouse models).

    “Genetic deletion or pharmacological inhibition of OTUB2 significantly ameliorated neuroinflammation and neurodegeneration in both ALS and aged mouse models.”

    AnimalsShown by genetic deletion in ALS and aged mouse models

    Blocking a protein reduced nerve cell degeneration in mice

    Brain : a journal of neurology

Inflammation

upin mice1

1 study
  1. OTUB2 increases inflammation in mice (Shown by genetic deletion in ALS and aged mouse models).

    “Genetic deletion or pharmacological inhibition of OTUB2 significantly ameliorated neuroinflammation and neurodegeneration in both ALS and aged mouse models.”

    AnimalsShown by genetic deletion in ALS and aged mouse models

    Blocking a protein reduced nerve cell degeneration in mice

    Brain : a journal of neurology

More on Inflammation

susceptibility to cellular senescence

upin human cells1

1 study
  1. OTUB2 increases susceptibility to cellular senescence in human cells (shown by depletion of OTUB2).

    “a shortening of G2 checkpoint activation by expression of SIRT6 or depletion of OTUB2 reduces susceptibility to senescence.”

    Cellsshown by depletion of OTUB2

    Defective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation

    Scientific reports

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 11 paper in 12 months
Brain

Blocking a protein reduced nerve cell degeneration in mice

Experiments in aged mice and mouse models of amyotrophic lateral sclerosis found less nervous system inflammation and degeneration after researchers deleted or inhibited…Experiments in aged mice and mouse models of amyotrophic lateral sclerosis found less nervous system inflammation and degeneration after researchers deleted or inhibited the protein.

Mouse studyMechanisms