OPA3

OPA3 decreases endogenous DNA damage in human cells.

“Functional assays demonstrated that knockdown of NFE2L2 and OPA3 increased endogenous DNA damage, supporting a role in genomic stability.”

Cellsshown by siRNA-mediated knockdownlung fibroblast

Large-scale association study identifies lung cancer susceptibility copy number variants and their potential functional role in genetic instability

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·Oct 19, 2026