CNV-based polygenic risk score

1. CNV-based polygenic risk score is associated with lung cancer in humans.

   “A CNV-based PRS constructed from four key genes (CLCN6, NFE2L2, OPA3, and PSMB8) was significantly associated with lung cancer risk and replicated across independent datasets.”

   Humans

   Large-scale association study identifies lung cancer susceptibility copy number variants and their potential functional role in genetic instability

   Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·Oct 19, 2026

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