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NKG7

Gene

3 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: Medical Research Council
  • Humans1
  • Animals1

Effects

2

Wound healing

downin mice2

2 studies

  1. NKG7 impairs wound healing in mice.

    “These cells impede myeloid-cell-dependent wound healing in the aged injured cord through expressing natural killer cell granule protein 7 (NKG7).”

    Reviewafter spinal cord injuryspinal cord

    A subtype of T cells impedes tissue repair in aged spinal cord after injury

    NeuronMar 5, 2025

  2. NKG7 impairs wound healing in mice.

    “NKLT cells expressing natural killer cell granule protein 7 (Nkg7) disrupt myeloid-cell-dependent wound healing in the aged injured cord.”

    Animalsaged injured spinal cord

    Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord to disrupt myeloid-dependent wound healing

    NeuronJan 13, 2025

Tissue repair

downin mice1

1 study

  1. NKG7 decreases tissue repair in mice.

    “Nkg7 deletion in mice curbs NKLT cell degranulation to normalize the myeloid cell phenotype, thus promoting tissue repair and axonal integrity.”

    Animalsshown by deletion in mice after SCI

    Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord to disrupt myeloid-dependent wound healing

    NeuronJan 13, 2025

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