NIT2

1. NIT2 decreases angiogenesis in mice.

   “Endothelial-specific knockout mice of NIT2 exhibited increased levels of αKGM and impaired angiogenesis.”

   Animalsendothelial-specific knockout

   The transaminase-ω-amidase pathway is a redox switch in glutamine metabolism that generates α-ketoglutarate

   bioRxiv (Cold Spring Harbor Laboratory)·Aug 29, 2024Preprint

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1. NIT2 is associated with α-ketoglutaramate in humans.

   “Furthermore, a variant in the NIT2 gene that decreases its expression is associated with high plasma αKGM level in humans.”

   Humansvariant decreasing expression

   The transaminase-ω-amidase pathway is a redox switch in glutamine metabolism that generates α-ketoglutarate

   bioRxiv (Cold Spring Harbor Laboratory)·Aug 29, 2024Preprint

More on α-ketoglutaramate