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Cell ReportsAnimals·28 Aug

Targeting pro-senescent PTGS2⁺ macrophages alleviates chondrocyte senescence and osteoarthritis progression

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PTGS21
SDC41
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Direct AMPK activation modestly lengthens lifespan in short-lived species

ResearchFight Aging!

Declining chaperone-mediated autophagy prevents macrophages from clearing senescent cells with age

ResearchNature Aging and 1 more

Senescence-inhibiting isoform Δ133p53α slows premature aging in mice

Researchnpj Aging

Trials

Registered6 Oct 2026

AKG and Brain Health in Aging

Phase 2 · University of Oklahoma

Registered2 Oct 2026

Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital)

Phase 1 · Vinmec Research Institute of Stem Cell and Gene Technology

Registered1 Oct 2026

Functional Mobility and Resistance Exercise for Postmenopausal Females With Type 1 Diabetes

Institut de Recherches Cliniques de Montreal

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