MRPL54

1. MRPL54 decreases mitochondrial-encoded protein content in mouse cells.

   “reduction in mitochondrial-encoded protein expression in myoblasts”

   Cellsmyoblasts

   Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice

   Scientific reports·24 May 2023

More on Mitochondrial-encoded protein content

1. MRPL54 has no effect on healthspan in mice.

   “Overall, we demonstrate that genetic manipulation of Mrpl54 expression reduces mitochondrial-encoded protein content but is not sufficient to improve healthspan in otherwise healthy and unstressed mice.”

   Animalsgermline heterozygous Mrpl54+/-

   Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice

   Scientific reports·24 May 2023

1. MRPL54 has no effect on lifespan in mice.

   “There were no differences in median life expectancy or maximum lifespan.”

   Animalsgermline heterozygous Mrpl54+/-

   Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice

   Scientific reports·24 May 2023