miro-1

1. miro-1 inhibits mitochondrial unfolded protein response in worms (Weakly activated in mutants).

   “The ROS damage is slightly reduced and the mitochondrial unfolded protein response pathway is weakly activated in miro-1 mutants.”

   Model organismsshown by mutation

   C. elegans miro-1 Mutation Reduces the Amount of Mitochondria and Extends Life Span

   PloS one·Apr 11, 2016

More on Mitochondrial unfolded protein response

1. miro-1 increases mitochondrial abundance in worms (Mutant mitochondrial abundance approximately 50% of wild-type).

   “Notably, the amount of mitochondria in the miro-1 mutant is reduced to approximately 50% of the wild-type.”

   Model organismsshown by mutation; compared with wild-type

   C. elegans miro-1 Mutation Reduces the Amount of Mitochondria and Extends Life Span

   PloS one·Apr 11, 2016

More on Mitochondrial abundance