There are 2 papers on MIR-31A-5P in aging research: none in people yet, 2 in animals.
2 papers study it3 findings
See all 2 papers on MIR-31A-5P
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funder: National Natural Science Foundation of China
- Animals2
Effects
2SATB2
downin rat cells1
1 study
SATB2
downin rat cells1
MIR-31A-5P decreases SATB2 in rat cells (gain-of-function and knockdown of miR-31a-5p).
“roles of miR-31a-5p in osteogenic differentiation by assessing the decrease of special AT-rich sequence-binding protein 2 (SATB2) levels”
Cellsgain-of-function and knockdown of miR-31a-5pbone marrow
Aging cell
Cellular senescence
upin rat cells1
1 study
Cellular senescence
upin rat cells1
MIR-31A-5P increases cellular senescence in rat cells (gain-of-function and knockdown of miR-31a-5p).
“the aging of BMSCs by regulating the decline of E2F2 and recruiting senescence-associated heterochromatin foci (SAHF)”
Cellsgain-of-function and knockdown of miR-31a-5pbone marrow
Aging cell
Upstream
1Age
upin rats1
1 study
Age
upin rats1
Age increases MIR-31A-5P in rats (aged versus young rats).
“the level of microRNA-31a-5p (miR-31a-5p) was significantly increased in bone marrow stromal cells (BMSCs) from aged rats”
Animalsaged versus young ratsbone marrow
Aging cell