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MIR-223-3P

There are 3 papers on MIR-223-3P in aging research: 1 trial in people, 2 in animals.

Gene

3 papers study it2 findings

See all 3 papers on MIR-223-3P

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Mice: a single group. Cells, worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Key Research and Development Program of China and 1 more
  • Human trial1
  • Animals2

Effects

2

Cellular senescence

upin mice1

1 study

  1. MIR-223-3P increases cellular senescence in mice (shown by overexpression, negated by KP1).

    “Overexpression of miR-223-3p inhibited Klotho and induced p21, p16 and γ-H2AX”

    Animalsshown by overexpression, negated by KP1

    Klotho-derived peptide 1 inhibits cellular senescence in the fibrotic kidney by restoring Klotho expression via posttranscriptional regulation

    Theranostics

More on Cellular senescence

KL

downin mice1

1 study

  1. MIR-223-3P decreases KL in mice (shown by binding to Klotho mRNA).

    “miR-223-3p that bound to Klotho mRNA and inhibited its protein expression”

    Animalsshown by binding to Klotho mRNAkidney

    Klotho-derived peptide 1 inhibits cellular senescence in the fibrotic kidney by restoring Klotho expression via posttranscriptional regulation

    Theranostics

More on KL

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