MIR-128-3P

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Funders: China Postdoctoral Science Foundation and 1 more

Animals1

Effects

Age-related bone loss

upin mice1

1 study

MIR-128-3P increases age-related bone loss in mice.
“osteoblastic miR-128-3p deficiency prevented age-related bone loss in mice.”
Animalsshown by osteoblastic miR-128-3p deficiencybone
MicroRNA-128-3p Deficiency Alleviates Bone Loss in Age-Related Osteoporosis via Activation of Canonical Wnt Signaling
Aging cell28 Mar 2026

Osteoblast differentiation

downin mouse cells1

1 study

MIR-128-3P inhibits osteoblast differentiation in mouse cells.
“miR-128-3p deletion in OBs stimulates osteoblastogenesis; its inhibition in MC3T3-E1 cells gave similar results.”
Cellsshown by deletion in osteoblasts and inhibition in MC3T3-E1 cellsosteoblast
MicroRNA-128-3p Deficiency Alleviates Bone Loss in Age-Related Osteoporosis via Activation of Canonical Wnt Signaling
Aging cell28 Mar 2026

Bone mass

downin mice1

1 study

MIR-128-3P decreases bone mass in mice.
“OB miR-128-3p conditional deletion (cKO, miR-128-3pOb-/-) markedly increased bone mass by increasing bone formation.”
Animalsshown by osteoblast-specific conditional deletionbone
MicroRNA-128-3p Deficiency Alleviates Bone Loss in Age-Related Osteoporosis via Activation of Canonical Wnt Signaling
Aging cell28 Mar 2026

Associations

Bone formation

downin humans1

1 study

MIR-128-3P is associated with bone formation in humans.
“the age-related miR-128-3p increase was negatively correlated with bone formation.”
Humansbone
MicroRNA-128-3p Deficiency Alleviates Bone Loss in Age-Related Osteoporosis via Activation of Canonical Wnt Signaling
Aging cell28 Mar 2026

Latest

1 in 12 months

Aging Cell28 Mar

MicroRNA-128-3p Deficiency Alleviates Bone Loss in Age-Related Osteoporosis via Activation of Canonical Wnt Signaling

Experiments in miceWnt/β-catenin signalling

Paper