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LYPLAL1-AS1

Gene

2 papers study it5 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 1 country
  • Funders: National Natural Science Foundation of China and 4 more
  • Humans2

Effects

2

Cellular senescence

downin human cells1

1 study

  1. LYPLAL1-AS1 inhibits cellular senescence in human cells.

    “LYPLAL1-AS1 overexpression attenuated it”

    Cellsoverexpressionadipose tissue

    LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation

    Cell & bioscienceApr 21, 2022

  2. LYPLAL1-AS1 prevents cellular senescence in human cells.

    “Knockdown of LYPLAL1-AS1 accelerated hADSC senescence”

    Cellsknockdownadipose tissue

    LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation

    Cell & bioscienceApr 21, 2022

More on Cellular senescence

MIRLET7B

downin human cells1

1 study

  1. LYPLAL1-AS1 inhibits MIRLET7B in human cells.

    “LYPLAL1-AS1 bound to the MIRLET7B promoter region and suppressed its transcription activity”

    CellsLYPLAL1-AS1 overexpressionadipose tissue

    LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation

    Cell & bioscienceApr 21, 2022

More on MIRLET7B

Associations

2

Sarcopenic obesity

upin humans1OR 1.15

1 study

  1. LYPLAL1-AS1 is associated with sarcopenic obesity in humans (OR 1.15, 95% CI 1.11-1.19).

    “Single-variant association analysis identified one locus 1q41 (lead SNP rs1417066, LYPLAL1-AS1, odds ratio [OR] = 1.15, 95% confidence interval [CI] = [1.11-1.19], p = 1.75 × 10-14)”

    Humans

    Exome-Wide Sequencing Study Identified Genetic Variants Associated With Sarcopenic Obesity

    The journals of gerontology. Series A, Biological sciences and medical sciencesJan 25, 2024

More on Sarcopenic obesity

Chronological age

downin humans1

1 study

  1. Chronological age is associated with LYPLAL1-AS1 in humans.

    “correlated negatively with age”

    Humanswhole-blood

    LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation

    Cell & bioscienceApr 21, 2022

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