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LCE2

Gene

1 paper studies it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Babraham Institute and others
  • Cells1

Upstream

2

CEBPB

is required forin human cells1

1 study

  1. CEBPB is required for LCE2 in human cells.

    “Decompaction of the locus is not sufficient for LCE2 expression, which requires p53 and C/EBPβ signaling.”

    Cellsfor LCE2 expression in senescence

    Locus-specific induction of gene expression from heterochromatin loci during cellular senescence

    Nature aging

More on CEBPB

Cellular senescence

upin human cells1

1 study

  1. Cellular senescence increases LCE2 in human cells.

    “we show that a small number of lineage-inappropriate genes, exemplified by the LCE2 skin genes, are derepressed during senescence from H3K9me3 regions in fibroblasts.”

    Cellsin senescent fibroblastsfibroblast

    Locus-specific induction of gene expression from heterochromatin loci during cellular senescence

    Nature aging

More on Cellular senescence

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