KLF12

2 papers study it2 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Funder: National Natural Science Foundation of China

Animals1
In silico1

Effects

2

SPHK1

downin human cells1

1 study

KLF12 inhibits SPHK1 in human cells.
“This phenotype was further confirmed to result from inhibition of SPHK1 by KLF12.”
Cellsgranulosa cell
Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production
The Journal of biological chemistryAug 4, 2023

Apoptosis

upin human cells1

1 study

KLF12 induces apoptosis in human cells.
“when endogenous KLF12 was knocked down, it rescued oxidative stress-induced apoptosis.”
Cellsoxidative stress-induced apoptosisgranulosa cell
Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production
The Journal of biological chemistryAug 4, 2023

More on Apoptosis

Latest

1 paper in 12 months

Preprints.orgDec 1

A Meta-Analysis of Microglial Heterogeneity and Gene Coexpression Networks in Aging and Neurodegeneration

Preprint: computational studyMechanisms

The Journal of Biological ChemistryAug 6

Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production

Experiments in animalsApoptosis