There are 4 papers on KCNB1 in aging research: none in people yet, 3 in animals.
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
Mice: a single group. Cells, worms or flies and humans: nothing yet.
- 1 lab in 1 country
- Funders: National Institute of Neurological Disorders and Stroke and 3 more
- Animals3
- In silico1
Effects
2Neurodegeneration
no changein mice1
1 study
Neurodegeneration
no changein mice1
KCNB1 showed no clear effect on neurodegeneration in mice (genotype comparison (Tg-C73A vs Tg-WT vs non-Tg)).
“neurodegeneration and neuronal loss were not significantly different in the various genotypes”
Animalsgenotype comparison (Tg-C73A vs Tg-WT vs non-Tg)brain
Biochemical and biophysical research communications
Working memory
downin mice1
1 study
Working memory
downin mice1
KCNB1 impairs working memory in mice (oxidation-induced oligomerization; shown with the non-oligomerizing C73A variant (Tg-C73A)).
“Aging mice in which KCNB1 oligomerization is negligible (Tg-C73A), performed significantly better in the Morris Water Maze (MWM) test of working memory compared to non-Tg or Tg-WT mice.”
Animalsoxidation-induced oligomerization; shown with the non-oligomerizing C73A variant (Tg-C73A)brain
Biochemical and biophysical research communications
Latest
1 paper in 12 monthsFrontiers in Neuroscience
AD diagnosis model based on fusion of heterogeneous brain imaging and genomic data
Computational studyBiomarkers
Brain, Behavior, and Immunity
Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice
Experiments in 42 miceHigh-fat diet
The Journal of Neuroscience
Dopamine-Dependent QR2 Pathway Activation in CA1 Interneurons Enhances Novel Memory Formation
Experiments in miceMechanisms
Biochemical and Biophysical Research Communications
Oxidation of KCNB1 potassium channels in the murine brain during aging is associated with cognitive impairment
Experiments in miceMechanisms