There are 3 papers on ITGB8 in aging research: 1 observational study in people, 2 in animals.
At a glance
The findings reach people, from one lab or study. 1 lab in 1 country; 1 trial.
“In non-carriers, we identify a genome-wide significant association at ITGB8 restricted to executive function”
Humans: a single group. Cells, worms or flies and mice: nothing yet.
- 1 lab in 1 country
- 1 trial
- Funders: ADNI and others
- 1 of 1 finding with company ties
- 1 of 1 trial sponsored by developers of drugs aimed at it
- Humans1
- Animals2
Associations
1Executive function
mixedin humans1
1 study
Executive function
mixedin humans1
ITGB8 is associated with executive function in non-carriers.
“In non-carriers, we identify a genome-wide significant association at ITGB8 restricted to executive function”
Humansin non-carriers
Genetic modifiers of APOE-ε4-associated cognitive decline
Nature communications
Latest
3 papers in 12 monthsExperimental & Molecular Medicine
Osteoblast-derived osteomodulin restrains osteoclastogenesis via ITGB8/RRM2-mediated reduction of mitochondrial respiration and mitochondrial ATP production
Experiments in miceOxidative phosphorylation
Nature Communications
Genetic modifiers of APOE-ε4-associated cognitive decline
Genetic association study of 32,778 peopleMechanisms
Communications Medicine
Selective blockade of latent TGF-β1 activation suppresses tissue fibrosis with good safety
Experiments in miceInterventions