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IM33

Gene

1 paper2 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Center for Complementary and Integrative Health and 3 more
  • Model organisms1

Effects

2

Lifespan

upin flies1

1 study

  1. IM33 extends lifespan in flies.

    “Knockdown of IM33 in glia elevates the gut reactive oxygen species (ROS) level and alters gut microbiota composition, including increased Lactiplantibacillus plantarum abundance, leading to a shortened lifespan.”

    Model organismsin glia

    A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan

    Neuron14 Aug 2023

Reactive oxygen species

downin flies1

1 study

  1. IM33 decreases reactive oxygen species in flies.

    “Knockdown of IM33 in glia elevates the gut reactive oxygen species (ROS) level”

    Model organismsin gliagut

    A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan

    Neuron14 Aug 2023

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