HIV-1TAT

1. HIV-1TAT decreases grip strength in mice.

   “reduced grip strength”

   Animalsmales

   Age-related neuroendocrine, cognitive, and behavioral co-morbidities are promoted by HIV-1 Tat expression in male mice

   Aging·Jul 12, 2022

1. HIV-1TAT impairs cognitive function in mice.

   “increased cognitive errors (radial arm water maze)”

   Animalsmales

   Age-related neuroendocrine, cognitive, and behavioral co-morbidities are promoted by HIV-1 Tat expression in male mice

   Aging·Jul 12, 2022

1. HIV-1TAT increases anxiety-like behavior in mice.

   “Older age or Tat exposure increased anxiety-like behavior (open field; elevated plus-maze)”

   Animalsmales

   Age-related neuroendocrine, cognitive, and behavioral co-morbidities are promoted by HIV-1 Tat expression in male mice

   Aging·Jul 12, 2022

1. HIV-1TAT increases corticosterone in mice.

   “greater circulating corticosterone and central allopregnanolone than other groups”

   AnimalsTat(+) vs other groupsmales

   Age-related neuroendocrine, cognitive, and behavioral co-morbidities are promoted by HIV-1 Tat expression in male mice

   Aging·Jul 12, 2022

More on Corticosterone

1. HIV-1TAT decreases testosterone in mice.

   “Middle-aged Tat(+) mice had lower circulating testosterone and progesterone than age-matched controls”

   AnimalsTat(+) vs Tat(-) controlsmales

   Age-related neuroendocrine, cognitive, and behavioral co-morbidities are promoted by HIV-1 Tat expression in male mice

   Aging·Jul 12, 2022

More on Testosterone