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HELLS

Gene

1 paper2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 2 countries
  • Funders: Alex's Lemonade Stand Foundation for Childhood Cancer and 6 more
  • Cells1

Effects

2

Lifespan

no changein human cells1

1 study

  1. HELLS has no effect on lifespan in human cells.

    “However, decreased PASG expression did not shorten the replicative life-span of TIG-7 cells.”

    CellsshRNA knockdown

    Stable knockdown of PASG enhances DNA demethylation but does not accelerate cellular senescence in TIG-7 human fibroblasts

    Epigenetics3 Sep 2008

DNA methylation

downin human cells1

1 study

  1. HELLS decreases DNA methylation in human cells.

    “The rate of demethylation of DNA was significantly increased in PASG-suppressed cells as compared control cells.”

    CellsshRNA knockdown

    Stable knockdown of PASG enhances DNA demethylation but does not accelerate cellular senescence in TIG-7 human fibroblasts

    Epigenetics3 Sep 2008

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