HBP1

1. HBP1 activates mitochondrial biogenesis (PGC-1α) in human cells.

   “Focused analysis revealed that high-mobility group (HMG)-box transcription factor 1 (Hbp1) levels regulate mitochondrial biogenesis”

   Cellsgranulosa cells

   Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve

   Cell death and differentiation·May 20, 2016

More on Mitochondrial biogenesis (PGC-1α)

1. HBP1 increases apoptosis in mice.

   “ablation of Hbp1 promoted follicle growth and oocyte production, and is associated with the reduced apoptotic signals in mouse GCs”

   Animalsshown by ablationgranulosa cells

   Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve

   Cell death and differentiation·May 20, 2016

More on Apoptosis

1. HBP1 decreases oocyte production in mice.

   “systemic or granulosa-specific but not oocyte-specific ablation of Hbp1 promoted follicle growth and oocyte production”

   Animalsshown by ablationovary

   Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve

   Cell death and differentiation·May 20, 2016

1. HBP1 decreases follicle growth in mice.

   “systemic or granulosa-specific but not oocyte-specific ablation of Hbp1 promoted follicle growth and oocyte production”

   Animalsshown by ablationovary

   Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve

   Cell death and differentiation·May 20, 2016