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HADHA

Gene

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: Japan Society for the Promotion of Science
  • 2 of 2 findings with company ties
  • Animals1

Interventions

1

Spermidine

upin mouse cells1

1 study

  1. Spermidine activates HADHA in mouse cells.

    “SPD bound to the α and β subunits of MTP with strong affinity and allosterically enhanced their enzymatic activities.”

    Cellspurified from Escherichia coli

    Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice

    Science (New York, N.Y.)28 Oct 2022

More on Spermidine

Effects

1

CD8+ T cell

is required forin mice1

1 study

  1. HADHA is required for CD8+ T cell in mice.

    “T cell-specific deletion of the MTP α subunit abolished enhancement of programmed cell death protein 1 (PD-1) blockade immunotherapy by SPD”

    AnimalsSPD-dependent T cell activation

    Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice

    Science (New York, N.Y.)28 Oct 2022

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