GPRC5C
There are 2 papers on GPRC5C in aging research: none in people yet, 2 in cells.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Barndiabetesfonden and others
- Cells2
Effects
4Cell proliferation
upin mouse cells1
1 study
Cell proliferation
upin mouse cells1
GPRC5C increases cell proliferation in mouse cells (shown by knockdown in clonal MIN6c4 cells).
“Gprc5c-KD in clonal MIN6c4 cells reduced cell proliferation and in murine islets increased apoptosis”
Cellsshown by knockdown in clonal MIN6c4 cells
Endocrine journal
Apoptosis
downin mouse cells1
1 study
Apoptosis
downin mouse cells1
GPRC5C decreases apoptosis in mouse cells (shown by knockdown).
“Gprc5c-KD in clonal MIN6c4 cells reduced cell proliferation and in murine islets increased apoptosis”
Cellsshown by knockdownpancreatic islets
Endocrine journal
Glucose-stimulated insulin secretion
is required forin mouse cells1
1 study
Glucose-stimulated insulin secretion
is required forin mouse cells1
GPRC5C is required for glucose-stimulated insulin secretion in mouse cells (glucose-stimulated insulin secretion).
“Potentiation of glucose-stimulated insulin secretion concomitant with enhanced islet cAMP level by all-trans retinoic acid (ATRA) was attenuated upon Gprc5c-KD.”
Cellsglucose-stimulated insulin secretion
Endocrine journal
Glucose-stimulated insulin release
downin mouse cells1
1 study
Glucose-stimulated insulin release
downin mouse cells1
GPRC5C decreases glucose-stimulated insulin release in mouse cells (shown by knockdown).
“Down-regulation of Gprc5c led to both moderately reduced glucose-stimulated insulin release and also reduced cAMP content in mouse islets.”
Cellsshown by knockdownpancreatic islets
Endocrine journal