Mirdametinib
Intervention1 paper1 findingPubChem 9826528ChEBI 88249
- Model organisms1
Outcomes
1Motor neurodegenerative phenotypes
downin flies1Very low certainty
1 study
Motor neurodegenerative phenotypes
downin flies1Very low certainty
Mirdametinib decreases motor neurodegenerative phenotypes in flies.
Model organismspeb mutant
RAS/MAPK overactivation drives motor axon loss in flies · iScience · 21 Sep 2026
Latest
1iScienceModel organisms
RAS/MAPK overactivation drives motor axon loss in flies
An unbiased genetic screen in Drosophila revealed that excessive RAS/MAPK signaling causes adult-onset neurodegeneration that a MEK inhibitor rescues…An unbiased genetic screen in Drosophila revealed that excessive RAS/MAPK signaling causes adult-onset neurodegeneration that a MEK inhibitor rescues in a dose-dependent manner.