GPR68

1 paper1 finding

Effects

Inflammation

upin reviews1

1 study

GPR68 activates inflammation.
“inducing NF-κB and NFAT nuclear translocation to upregulate inflammatory mediators such as IL-6, TNF-α, and COX-2.”
Reviewvia Gq/11-PLC-IP3/Ca2+ signaling
Acid sensing to inflammaging: mechanisms and therapeutic promise of GPR68 (OGR1) in aging-related diseases
Frontiers in aging20 Oct 2025

Frontiers in Aging5 Nov