What does the research say about GHRD3?

GHRD3

There is 1 paper on GHRD3 in aging research: none in people yet, 1 in animals.

1 paper studies it5 findings

The findings reach people, from one lab or study. 1 lab in 1 country.

“GHRd3 is associated with protection from edematous severe acute malnutrition primarily in males”

None of its findings points the other way.

Allele frequency in East Asia

downin silico1

1 study

GHRD3 decreases allele frequency in East Asia in silico (approximately 30 thousand years ago).
“it underwent a paradoxical adaptive reduction in frequency approximately 30 thousand years ago in East Asia”
In silicoapproximately 30 thousand years ago
Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptor
bioRxiv (Cold Spring Harbor Laboratory)Oct 1, 2019Preprint

Sex difference in body weight

downin mice1

1 study

GHRD3 decreases sex difference in body weight in mice under calorie restriction.
“the dramatic weight difference between male and female mice disappears among GHRd3 mice under calorie restriction”
Animalsunder calorie restriction
Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptor
bioRxiv (Cold Spring Harbor Laboratory)Oct 1, 2019Preprint

Female-like liver gene expression

upin mice1

1 study

GHRD3 induces female-like liver gene expression in mice under calorie restriction.
“In contrast, under calorie restriction, Ghrd3 leads to the female-like gene expression in male livers”
Animalsunder calorie restrictionlivermales
Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptor
bioRxiv (Cold Spring Harbor Laboratory)Oct 1, 2019Preprint

Calorie restriction-like liver transcriptome

upin mice1

1 study

GHRD3 induces calorie restriction-like liver transcriptome in mice (male mice grown without calorie restriction; mediated through circadian pathways).
“Ghrd3 ’s effect on the liver transcriptome of male mice grown without any calorie restriction mimics response to calorie restriction through regulation of circadian pathways”
Animalsmale mice grown without calorie restriction; mediated through circadian pathwayslivermales
Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptor
bioRxiv (Cold Spring Harbor Laboratory)Oct 1, 2019Preprint

Edematous severe acute malnutrition

downin humans1

1 study

GHRD3 is linked with less edematous severe acute malnutrition in humans (primarily in males).
“GHRd3 is associated with protection from edematous severe acute malnutrition primarily in males”
Humansprimarily in malesmales
Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptor
bioRxiv (Cold Spring Harbor Laboratory)Oct 1, 2019Preprint

bioRxivOct 1

Preprint: experiments in miceMechanisms