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Gba1b

Gene

1 paper2 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Institute of Neurological Disorders and Stroke and 3 more
  • Model organisms1

Effects

2

Behavioral deficits

upin flies1

1 study

  1. Gba1b improves behavioral deficits in flies.

    “rescued their lifespan and behavioral deficits”

    Model organismsin activated macrophages in Gba1b mutantsmacrophage

    Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation

    PLoS geneticsNov 11, 2024

Lifespan

upin flies1

1 study

  1. Gba1b extends lifespan in flies.

    “re-expressing Gba1b in activated macrophages suppressed head protein aggregation in Gba1b mutants and rescued their lifespan”

    Model organismsin activated macrophages in Gba1b mutantsmacrophage

    Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation

    PLoS geneticsNov 11, 2024

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