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flp-2

Gene

2 papers2 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: Fondation pour la Recherche Médicale and 4 more
  • 1 of 2 findings with company ties
  • Model organisms2

Effects

1

Lifespan

no changein worms1

1 study

  1. flp-2 has no effect on lifespan in worms.

    “loss of flp-2 function did not affect lifespan or paraquat tolerance”

    Model organismsshown by loss-of-function mutation

    frpr-18, a neuropeptide receptor, regulates organismal lifespan and stress tolerance in C. elegans

    microPublication biologyJun 12, 2023

Associations

1

Lifespan

mixedin worms1

1 study

  1. flp-2 is associated with lifespan in worms.

    “FLP-2 is involved in not only larval development but also adult lifespan by regulating the secretion of one of the insulin-like peptides INS-35”

    Model organisms

    The FMRFamide-like peptide FLP-2 is involved in the modulation of larval development and adult lifespan by regulating the secretion of the insulin-like peptide INS-35 in Caenorhabditis elegans

    Bioscience, biotechnology, and biochemistryJul 6, 2022

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