FERMT2

1 paper1 finding

HGNC NCBI Gene Taxon

1 lab in 1 country

Funders: National Key Project for Synthetic Biology and 4 more

Animals1

Interventions

1

Methylmalonic acid

downin mouse cells1

1 study

Methylmalonic acid decreases FERMT2 in mouse cells.
“MMA binds directly to Kindlin-2 via a positively charged motif in its UBL domain, promoting Kindlin-2 ubiquitination and degradation, which accelerates skeletal aging.”
Cells
Kindlin-2 functional restoration through methylmalonic acid clearance by coenzyme A counteracts osteoporosis
Molecular therapy : the journal of the American Society of Gene Therapy27 May 2026

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Molecular Therapy27 May

Kindlin-2 functional restoration through methylmalonic acid clearance by coenzyme A counteracts osteoporosis

Experiments in miceBones and joints