dct-1

3 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Funders: National Center for Research Resources and 1 more

Animals1
Model organisms2

Effects

Mitophagy

mediatesin worms1

1 study

dct-1 mediates mitophagy in worms.
“DCT-1 is a key mediator of mitophagy and longevity assurance under conditions of stress in C. elegans”
Model organismsunder conditions of stress
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans
Nature20 Apr 2015

Upstream

skn-1

upin worms1

1 study

skn-1 increases dct-1 in worms.
“triggers mitochondrial retrograde signalling through the SKN-1 transcription factor that regulates both mitochondrial biogenesis genes and mitophagy by enhancing DCT-1 expression”
Model organismsmitochondrial retrograde signalling during impaired mitophagy
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans
Nature20 Apr 2015