daf-2mutation

1. daf-2mutation extends lifespan in worms.

   “We demonstrate that a classic insulin receptor mutation extends male survival to an unprecedented extreme, vastly surpassing the established benchmarks of the field.”

   Model organismsdaf-2 mutantmales

   Fourfold lifespan extension in C. elegans daf-2 mutant males

   eLife·13 Jul 2026Preprint

2. daf-2mutation extends lifespan in worms (Fourfold lifespan extension).

   “We demonstrate that a classic insulin receptor mutation extends male survival to an unprecedented extreme, vastly surpassing the established benchmarks of the field.”

   Model organismsdaf-2 mutationmales

   Fourfold lifespan extension in C. elegans daf-2 mutant males

   eLife·13 Jul 2026Preprint

1. daf-2mutation increases neutral lipid in worms.

   “it fuels a male-specific metabolic reprogramming that uncouples aging from stunted growth—massively accumulating neutral lipids to support sustained somatic preservation.”

   Model organismsdaf-2 mutationmales

   Fourfold lifespan extension in C. elegans daf-2 mutant males

   eLife·13 Jul 2026Preprint

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