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CRYBA1

Gene

3 papers study it1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Israel National Institute for Health Policy Research and 5 more
  • Animals3

Effects

1

mTOR signaling

downin mice1

1 study

  1. CRYBA1 inhibits mTOR signaling in mice.

    “Inhibition of mTOR with TORIN1 in vitro or βA3/A1-crystallin in vivo normalized mTORC1/2 activity and restored function”

    Animalsin vivo in mLST8-overexpressing mice

    Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD-Like Pathology in Mice

    Aging cell

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