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COMT

Gene

3 papers2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • 1 trial
  • Funder: National Institute on Aging
  • Humans3

Associations

2

Brain COMT

upin humans1

1 study

  1. COMT is associated with brain COMT in humans.

    “each additional Val allele was associated with higher brain COMT (p < 0.0001).”

    HumansCOMT Val158Metbraineach additional Val allele

    Diet’s link to dementia differed by gene variant in older adults

    Nutrients30 Sep 2026

More on Brain COMT

Association between MIND diet adherence and dementia incidence

mixedin humans1

1 study

  1. COMT is associated with association between MIND diet adherence and dementia incidence in humans (Interaction p = 0.003 for Alzheimer's dementia; p = 0.004 for all-cause dementia).

    “Significant COMT × MIND interactions were observed for Alzheimer's (p = 0.003) and all-cause (p = 0.004) dementia”

    HumansCOMT Val158Met interaction with MIND adherencen = 745

    Diet’s link to dementia differed by gene variant in older adults

    Nutrients30 Sep 2026

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Nutrients

Diet’s link to dementia differed by gene variant in older adults

In one genetic group, each extra diet-score point was linked to lower relative Alzheimer’s dementia risk over time (hazard ratio 0.82).In one genetic group, each extra diet-score point was linked to lower relative Alzheimer’s dementia risk over time (hazard ratio 0.82).

Cohort study of 745 older adultsAll-cause dementia

Limit: Questionnaire-based diet estimates may misclassify adherence and distort genotype-specific associations

Paper

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