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clp-1

Gene

1 paper1 finding

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Model organisms1

Effects

1

Early-onset neurodegeneration

upin worms1

1 study

  1. clp-1 increases early-onset neurodegeneration in worms.

    “we found that this early-onset neurodegeneration can be suppressed in clp-1 mutants”

    Model organismsshown by suppression in clp-1 mutantsneuron

    Mechanical load conditions the spectrin network to ‘runon’ proteolysis and promotes early onset neurodegeneration

    bioRxiv (Cold Spring Harbor Laboratory)4 Nov 2024Preprint

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