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CIRCVMN2R1

There are 2 papers on CIRCVMN2R1 in aging research: none in people yet, 2 in animals. The newest story, Nov 9, 2026: “Gut microbe-derived compound promotes kidney aging in mice”.

Gene

2 papers study it4 findings

1 new paper in 30 daysSee all 2 papers on CIRCVMN2R1

At a glance

The findings reach mice, none yet in people; independent labs found the same change in cells. 2 independent labs in 1 country.

None of its findings points the other way.

Cells: replicated by independent labs. Mice: a single group. Worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 1 country
  • Funders: Key Research and Development Projects of Shaanxi Province and 1 more
  • Animals2

Effects

3

Cellular senescence

upin mouse cells2

2 studies

  1. CIRCVMN2R1 increases cellular senescence in mouse cells (TMAO treatment; shown by circVmn2r1 knockdown).

    “genetic knockdown of circVmn2r1 in vitro and in vivo significantly attenuates TMAO-induced NLRP3 upregulation, inflammasome activation, and cellular senescence.”

    CellsTMAO treatment; shown by circVmn2r1 knockdown

    Gut microbe-derived compound promotes kidney aging in mice

    Renal failure

  2. CIRCVMN2R1 increases cellular senescence in mouse cells (gain-of-function in TCMK-1 cells).

    “circVmn2r1 inhibited proliferation and promoted senescence, whereas miR-223-3p counteracted these effects”

    Cellsgain-of-function in TCMK-1 cells

    Circular RNA CircVmn2r1 Acts as a miR-223-3p Sponge to Promote Kidney Aging by Regulating NLRP3 Expression in Mice

    The journals of gerontology. Series A, Biological sciences and medical sciences

More on Cellular senescence

NLRP3

upin mouse cells1

1 study

  1. CIRCVMN2R1 increases NLRP3 in mouse cells (by sponging miR-223-3p).

    “circVmn2r1 promotes kidney aging through acting as a miR-223-3p sponge, consequently upregulating NLRP3 expression”

    Cellsby sponging miR-223-3p

    Circular RNA CircVmn2r1 Acts as a miR-223-3p Sponge to Promote Kidney Aging by Regulating NLRP3 Expression in Mice

    The journals of gerontology. Series A, Biological sciences and medical sciences

More on NLRP3

Kidney aging

upin mice1

1 study

  1. CIRCVMN2R1 increases kidney aging in mice (shown by overexpression in SAMP8 mice).

    “overexpression of circVmn2r1 promoted kidney aging in senescence-accelerated mouse prone 8 mice”

    Animalsshown by overexpression in SAMP8 micekidney

    Circular RNA CircVmn2r1 Acts as a miR-223-3p Sponge to Promote Kidney Aging by Regulating NLRP3 Expression in Mice

    The journals of gerontology. Series A, Biological sciences and medical sciences

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 11 paper in 12 months
Renal Failure

Gut microbe-derived compound promotes kidney aging in mice

Reducing a circular RNA weakened the compound’s effects in male mice given it in drinking water for 16 weeks.Reducing a circular RNA weakened the compound’s effects in male mice given it in drinking water for 16 weeks.

Mouse studyKidney
Paper

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