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cdk-4

Gene

1 paper studies it2 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Canadian Institutes of Health Research and 3 more
  • Model organisms1

Effects

2

Motility

downin worms1

1 study

  1. cdk-4 impairs motility in worms.

    “Worms with depleted CDK-4 exhibited accelerated aging phenotypes, including reduced lifespan, decreased motility, increased yolk accumulation, and earlier onset of senescence.”

    Model organismsconditional degradation

    CDK-4 regulates nucleolar size and metabolism at the cost of late-life fitness in C. elegans

    Heredity

Lifespan

downin worms1

1 study

  1. cdk-4 shortens lifespan in worms.

    “Worms with depleted CDK-4 exhibited accelerated aging phenotypes, including reduced lifespan, decreased motility, increased yolk accumulation, and earlier onset of senescence.”

    Model organismsconditional degradation

    CDK-4 regulates nucleolar size and metabolism at the cost of late-life fitness in C. elegans

    Heredity

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