BRE1
- 2 independent labs in 1 country
- Funders: National Natural Science Foundation of China and 6 more
- Cells2
Effects
3Lifespan
upin yeast cells1
1 study
Lifespan
upin yeast cells1
BRE1 extends lifespan in yeast cells.
“Lack of Bre1 or abolishment of the ubiquitination stabilizes Set2 protein, sustains H3K36me3 levels at the aging-related gene loci, and upregulates their gene expression, thus leading to extended chronological lifespan.”
Cellslack of Bre1 or abolishment of ubiquitination
Gcn5- and Bre1-mediated Set2 degradation promotes chronological aging of Saccharomyces cerevisiae
Cell reportsOct 4, 2023
Subtelomeric nucleosome instability
downin yeast cells1
1 study
Subtelomeric nucleosome instability
downin yeast cells1
BRE1 decreases subtelomeric nucleosome instability in yeast cells.
“deletion of BRE1 or mutation of H2BK123R results in nucleosome instability at subtelomeric regions.”
Cellsshown by BRE1 deletion
DNA repairSep 17, 2018
subtelomeric Y' recombination
downin yeast cells1
1 study
subtelomeric Y' recombination
downin yeast cells1
BRE1 inhibits subtelomeric Y' recombination in yeast cells.
“increases the recombination of subtelomeric Y' element that is required for telomere maintenance and survivor generation.”
Cellsshown by BRE1 deletion in yku70Δ mre11Δ cells
DNA repairSep 17, 2018
Latest
Cell Reports
Gcn5- and Bre1-mediated Set2 degradation promotes chronological aging of Saccharomyces cerevisiae
Experiments in yeastMechanisms