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ANK2

Gene

2 papers3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Muscular Dystrophy Association and 3 more
  • Animals2

Effects

3

Lifespan

downin mice1

1 study

  1. ANK2 shortens lifespan in mice.

    “as well as costs in earlier senescence and reduced lifespan.”

    Animalsankyrin-B(+/-)

    Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence

    PloS one17 Oct 2007

Cellular senescence

upin mice1

1 study

  1. ANK2 induces cellular senescence in mice.

    “as well as costs in earlier senescence and reduced lifespan.”

    Animalsankyrin-B(+/-)

    Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence

    PloS one17 Oct 2007

More on Cellular senescence

Cardiac contractility

upin mice1

1 study

  1. ANK2 improves cardiac contractility in mice.

    “Studies with the ankyrin-B(+/-) mouse reveal both benefits of enhanced cardiac contractility”

    Animalsankyrin-B(+/-)

    Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence

    PloS one17 Oct 2007

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