Symptomatic knee osteoarthritis

1. Symptomatic knee osteoarthritis is associated with Klemera-Doubal method biological age in humans (59.97 vs. 58.76 years, p < 0.001).

   “Participants with symptomatic KOA had a significantly higher mean BA than those without (59.97 vs. 58.76 years, p < 0.001).”

   Humans

   Biological age threshold is associated with symptomatic knee osteoarthritis risk in chinese adults: Insights from machine learning analysis of a national cohort

   PloS one·17 Dec 2025

2. Klemera-Doubal method biological age raises the risk of symptomatic knee osteoarthritis in humans (OR 1.0123, 95% CI 1.0049-1.0197).

   “each 1-year BA increase was associated with 1.23% higher symptomatic KOA odds (OR=1.0123, 95% CI:1.0049-1.0197, p = 0.0010).”

   Humans

   Biological age threshold is associated with symptomatic knee osteoarthritis risk in chinese adults: Insights from machine learning analysis of a national cohort

   PloS one·17 Dec 2025

More on Klemera-Doubal method biological age

1. Obesity raises the risk of symptomatic knee osteoarthritis in humans (2 in 3).

   “Lifetime risk rose with increasing BMI, with a risk of 2 in 3 among those who were obese.”

   Humansobesen = 3,068

   Lifetime risk of symptomatic knee osteoarthritis

   Arthritis and rheumatism·15 Sep 2008

More on Obesity

1. Knee injury raises the risk of symptomatic knee osteoarthritis in humans (56.8% (95% CI 48.4-65.2%)).

   “Cohort members with history of a knee injury had a lifetime risk of 56.8% (95% CI 48.4-65.2%).”

   Humansn = 3,068

   Lifetime risk of symptomatic knee osteoarthritis

   Arthritis and rheumatism·15 Sep 2008