Structural valve deterioration

1. Female sex was not clearly linked with structural valve deterioration in humans after transcatheter aortic valve implantation (HR 0.99, 95% CI 0.78-1.25, P = 0.90).

   “The development of SVD was comparable (hazard ratio, 0.99; 95% confidence interval, 0.78-1.25, P = 0.90)”

   Humansafter transcatheter aortic valve implantationmedian follow-up of 1844 daysfemalesn = 511

   Long-Term Impact of Gender Differences After Transcatheter Aortic Valve Implantation

   CJC open·Aug 30, 2024

1. Structural valve deterioration is associated with mortality in humans after TAVI (adjusted HR 2.12, 95% CI: 1.49-3.00).

   “SVD was associated with increased 10-year rates of all-cause mortality (adjusted hazard ratio 2.12, 95% CI: 1.49-3.00; p<0.001)”

   Humansafter TAVI10-year

   Predictors of long-term structural valve deterioration and failure after transcatheter aortic valve implantation

   EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Jan 19, 2026

1. Early residual mean postprocedural gradient predicts structural valve deterioration in humans (severe aortic valve stenosis after TAVI) (adjusted sHR 1.05, 95% CI: 1.01-1.08).

   “in the multivariable analysis, ERMPG was an independent predictor of SVD (adjusted subdistribution hazard ratio [sHR] 1.05, 95% confidence interval [CI]: 1.01-1.08; p=0.004).”

   Humanssevere aortic valve stenosis after TAVI

   Predictors of long-term structural valve deterioration and failure after transcatheter aortic valve implantation

   EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Jan 19, 2026

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