Spinal muscular atrophy type 3

1. Spinal muscular atrophy type 3 has no effect on leptin in humans.

   “whereas there was no significant difference in serum leptin concentrations.”

   Humansin adult patients with SMA type 3 compared to healthy controls

   Adiponectin and Leptin-Considerations in Adult Patients with Spinal Muscular Atrophy Type 3

   Diagnostics (Basel, Switzerland)·21 Feb 2025

More on Leptin

1. Spinal muscular atrophy type 3 raises the risk of insulin resistance in humans (91.3% vs 64.7% (HOMA-IR) or 44.4% (ISI Matsuda)).

   “Insulin resistance was present in 91.3% of patients with SMA type 3, as determined by HOMA-IR and ISI Matsuda insulin sensitivity markers.”

   Humansin adult patients with SMA type 3 vs controls

   Adiponectin and Leptin-Considerations in Adult Patients with Spinal Muscular Atrophy Type 3

   Diagnostics (Basel, Switzerland)·21 Feb 2025

More on Insulin resistance