Spinal diseases

1 paper4 findings

Humans1

Associations

4

EDN1

upin silico1

1 study

EDN1 is associated with spinal diseases in silico.
“four (KAT5, EZH2, BMP2, and EDN1) showing moderate to strong colocalization evidence across multiple disorders”
In silico
Causal relationship between circadian rhythm-related genes expression and spinal disorders: systematic druggable genome-wide Mendelian randomization analysis and virtual screening
Naunyn-Schmiedeberg's archives of pharmacology13 Jan 2026

BMP2

upin silico1

1 study

BMP2 is associated with spinal diseases in silico.
“four (KAT5, EZH2, BMP2, and EDN1) showing moderate to strong colocalization evidence across multiple disorders”
In silico
Causal relationship between circadian rhythm-related genes expression and spinal disorders: systematic druggable genome-wide Mendelian randomization analysis and virtual screening
Naunyn-Schmiedeberg's archives of pharmacology13 Jan 2026

EZH2

upin silico1

1 study

EZH2 is associated with spinal diseases in silico.
“four (KAT5, EZH2, BMP2, and EDN1) showing moderate to strong colocalization evidence across multiple disorders”
In silico
Causal relationship between circadian rhythm-related genes expression and spinal disorders: systematic druggable genome-wide Mendelian randomization analysis and virtual screening
Naunyn-Schmiedeberg's archives of pharmacology13 Jan 2026

KAT5

upin silico1

1 study

KAT5 is associated with spinal diseases in silico.
“four (KAT5, EZH2, BMP2, and EDN1) showing moderate to strong colocalization evidence across multiple disorders”
In silico
Causal relationship between circadian rhythm-related genes expression and spinal disorders: systematic druggable genome-wide Mendelian randomization analysis and virtual screening
Naunyn-Schmiedeberg's archives of pharmacology13 Jan 2026

Trial sponsors

Tangdu Hospital
1 trialPhase 4212 people
Poznan University of Medical Sciences
1 trialPhase 4150 people
Aristotle University Of Thessaloniki
1 trialPhase 472 people

Latest

3 in 12 months

Research Square3 Sep

Medullary Contact Channels of the Vertebral Endplate: A Histomorphometric Study by Age and Spinal Segment

Preprint: cross-sectional study of 41 peopleMechanisms

Aging Cell20 Mar

FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3

Experiments in ratsIntervertebral disc degeneration

Naunyn-Schmiedeberg's Archives of Pharmacology13 Jan

Causal relationship between circadian rhythm-related genes expression and spinal disorders: systematic druggable genome-wide Mendelian randomization analysis and virtual screening

Mendelian randomisation in peopleMechanisms