What does the research say about severe cognitive decline?

Severe cognitive decline

There are 2 papers on severe cognitive decline in aging research: 3 observational studies in people. The newest story, Nov 13, 2026: “Hobbies linked to lower risk of cognitive decline in older adults”.

Disease

2 papers study it38 more mention it3 findings

1 new paper in 30 daysSee all 41 papers on severe cognitive decline

“level of education (OR 0.10 (95%CI 0.02–0.37), p < 0.01)”

Factors associated with severe cognitive decline in community-dwelling older persons in Cameroon (Sub-Saharan African)Research Square2024doi:10.21203/rs.3.rs-3818956/v1

Humans3

Associations

Instrumental Activities of Daily Living

downin humans1OR 0.12

1 study

Instrumental Activities of Daily Living is linked with a lower risk of severe cognitive decline in humans (multivariate analysis) (OR 0.12 (95%CI 0.03–0.38)).
“IADL score (OR 0.12 (95%CI 0.03–0.38), p < 0.001)”
Humansmultivariate analysisn = 403
Factors associated with severe cognitive decline in community-dwelling older persons in Cameroon (Sub-Saharan African)
Research SquareJan 3, 2024Preprint

More on Instrumental Activities of Daily Living

Body mass index

downin humans1OR 0.88

1 study

Body mass index is linked with a lower risk of severe cognitive decline in humans (multivariate analysis) (OR 0.88 (95%CI 0.78–0.99)).
“body mass index (OR 0.88 (95%CI 0.78–0.99), p = 0.03)”
Humansmultivariate analysisn = 403
Factors associated with severe cognitive decline in community-dwelling older persons in Cameroon (Sub-Saharan African)
Research SquareJan 3, 2024Preprint

Latest

7 papers in 12 months

European Journal of AgeingNov 13

Hobbies linked to lower risk of cognitive decline in older adults

Older adults with hobbies had a 20–40% lower relative risk of moving from normal cognition to mild decline in three of four cohorts, compared with nonparticipants.Older adults with hobbies had a 20–40% lower relative risk of moving from normal cognition to mild decline in three of four cohorts, compared with nonparticipants.

Cohort · 123,802 peoplePopulations

Paper

Research SquareJan 3

Factors associated with severe cognitive decline in community-dwelling older persons in Cameroon (Sub-Saharan African)

Preprint: cross-sectional study of 403 peoplePopulations

Paper

European Geriatric MedicineNov 28

COVID-19 mortality risk factors in older people in a long-term care center

Cohort study of 100 peopleCOVID-19

Paper

Nature MedicineAug 26

Brain cell changes linked to cognitive decline in older people

An observational study linked cognitive decline from ages 70 to 82 with changes in the brain’s insulation and the cells that make it.An observational study linked cognitive decline from ages 70 to 82 with changes in the brain’s insulation and the cells that make it.

Cohort · 14 peopleMechanisms