Senescence-associated diseases

1 paper

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Aging Cell11 Sep

Transmembrane Protein PTCHD4 Is a Novel Regulator of Cellular Senescence and Age-Related Pathologies

Experiments in miceCellular senescence

Nature Communications28 Feb

ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation

Experiments in miceSenescence-associated secretory phenotype (SASP)

Nature Metabolism14 Dec

Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype

Experiments in miceSenescence-associated secretory phenotype (SASP)

Genes & Development1 Dec

Senescence and the SASP: many therapeutic avenues

ReviewSenescence-associated secretory phenotype (SASP)

Nature17 Jun

Senolytic CAR T cells reverse senescence-associated pathologies

Experiments in miceBlood and immune system

EBioMedicine18 Sep

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Non-randomised trial in 9 peopleSenolytics

EBioMedicine5 Jan

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Non-randomised trial in 14 peopleSenolytics

Cancer Science18 Apr

Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases

ReviewSenescence-associated secretory phenotype (SASP)