Secondary fracture

1. Osteoporosis treatment has no effect on secondary fracture in humans (30% vs 29%).

   “Unadjusted comparisons indicated that newly initiated treatment did not reduce secondary fracture risk”

   Humansnewly initiated treatment vs non-treatmentaverage follow-up of 4.4 yearsn = 247

   Efficacy of Osteoporosis Treatment in Nonagenarians With Proximal Femoral Fractures: A Retrospective Cohort Study

   Cureus·Sep 21, 2025

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1. Fracture liaison service is associated with secondary fracture in humans (0 to 37%).

   “The incidence of secondary fractures in these 11 systematic reviews ranged from 0 to 37%.”

   Reviewafter implementation of fracture liaison service programs

   Incidence of Secondary Fractures After Implementation of Different Models of FLS Secondary Prevention Programs: Scoping Review

   Archives of medical research·Dec 13, 2024

2. Fracture liaison service lowers the risk of secondary fracture in humans (from 11.8% to 4.9%).

   “significantly decreased the 1-year refracture rate from 11.8% to 4.9%”

   Human trialafter hip fracture surgery1 year

   Multipronged Programmatic Strategy for Preventing Secondary Fracture and Facilitating Functional Recovery in Older Patients after Hip Fractures: Our Experience in Taipei Municipal Wanfang Hospital

   Medicina (Kaunas, Lithuania)·Jun 30, 2022

3. Fracture liaison service lowers the risk of secondary fracture in humans (0.4% (n = 1)).

   “0.4% (n = 1) had an imminent fracture within 2 years.”

   Human trialvertebral compression fracture2 yearsn = 226

   The first reported fracture liaison service (FLS) for vertebral fractures in China: is muscle the missing gap?

   Archives of osteoporosis·Nov 6, 2021

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1. Osteoporosis treatment lowers the risk of secondary fracture in humans (11% vs 30% and 29%, p = 0.009).

   “The incidence of secondary fractures was significantly lower in the pre-existing treatment group (7/64 (11%)) than in the new treatment (15/50 (30%)) and non-treatment (38/133 (29%)) groups (p = 0.009).”

   Humanspre-existing treatment vs non-treatment and new treatmentaverage follow-up of 4.4 yearsn = 247

   Efficacy of Osteoporosis Treatment in Nonagenarians With Proximal Femoral Fractures: A Retrospective Cohort Study

   Cureus·Sep 21, 2025

More on Osteoporosis treatment

1. Not receiving osteoporosis medication raises the risk of secondary fracture in humans (HR 1.47, 95% CI 1.14-1.89).

   “not receiving osteoporosis medication (HR: 1.47, 95 % CI: 1.14-1.89)”

   Humansin patients with hip fractures

   Regional disparities in the risk of secondary fractures in patients with hip fractures

   Injury·Sep 5, 2024

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1. Age ≥71 years raise the risk of secondary fracture in humans (HR 1.23, 95% CI 1.01-1.44).

   “age ≥71 years (HR: 1.23, 95 % CI: 1.01-1.44)”

   Humansin patients with hip fractures

   Regional disparities in the risk of secondary fractures in patients with hip fractures

   Injury·Sep 5, 2024

1. Female sex raises the risk of secondary fracture in humans (HR 1.30, 95% CI 1.08-1.57).

   “the factors that increased their risk included female sex (HR: 1.30, 95 % CI: 1.08-1.57)”

   Humansin patients with hip fractures

   Regional disparities in the risk of secondary fractures in patients with hip fractures

   Injury·Sep 5, 2024

1. residing in medically vulnerable areas raise the risk of secondary fracture in humans (HR 1.24, 95% CI 1.05-1.47).

   “Patients residing in vulnerable areas had a higher risk of secondary fractures than did those residing in non-vulnerable areas (hazard ratio [HR]: 1.24, 95 % confidence interval [CI]: 1.05-1.47)”

   Humansin patients with hip fractures

   Regional disparities in the risk of secondary fractures in patients with hip fractures

   Injury·Sep 5, 2024

1. Very high fracture risk osteoporosis raises the risk of secondary fracture in humans.

   “The risk factor of both secondary fracture and mortality was very high fracture risk osteoporosis”

   Humanspostoperative female patients with proximal femoral fracturefemales

   Secondary fracture and mortality risk with very high fracture risk osteoporosis and proximal femoral fracture

   Journal of bone and mineral metabolism·Feb 3, 2024

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1. Anti-osteoporosis therapy lowers the risk of secondary fracture in humans (P < 0.001).

   “significant reduction of secondary fracture risk by anti-osteoporotic therapy (P < 0.001)”

   Humansn = 43,310

   Effects of anti-osteoporosis therapy on the risk of secondary fractures and surgical complications following surgical fixation of proximal humerus fracture in older people

   Age and ageing·Jun 1, 2023

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1. Functional Independence Measure is associated with secondary fracture in humans.

   “patients who used sleeping pills and had a lower functional independence measure had an increased risk for developing secondary fractures”

   Humansunder FLS during COVID-19 pandemic1 yearn = 172

   Secondary fracture rates and risk factors 1 year after a proximal femoral fracture under FLS

   Journal of bone and mineral metabolism·Apr 10, 2023

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1. Hypnotics and sedatives raise the risk of secondary fracture in humans.

   “patients who used sleeping pills and had a lower functional independence measure had an increased risk for developing secondary fractures”

   Humansunder FLS during COVID-19 pandemic1 yearn = 172

   Secondary fracture rates and risk factors 1 year after a proximal femoral fracture under FLS

   Journal of bone and mineral metabolism·Apr 10, 2023

More on Hypnotics and sedatives