Re-fracture

1. Fracture liaison services lower the risk of Re-fracture in humans.

   “FLS programs, although resource-intensive, significantly reduce re-fracture rates and associated costs.”

   Review

   The economic benefits of fracture prevention

   Expert review of pharmacoeconomics & outcomes research·Jul 24, 2025

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1. Acute-phase reaction is associated with Re-fracture in humans (sub-distribution HR 0.27, 95% CI 0.11-0.70, P-value = 0.007).

   “APR+ patients had a significantly reduced risk of re-fracture compared with APR- patients with a sub-distribution HR, 0.27 (95% CI, 0.11-0.70; P-value = 0.007).”

   Humanselderly osteoporotic fracture patients after initial zoledronic acid infusionaxillaryn = 674

   The impact of acute-phase reaction on mortality and re-fracture after zoledronic acid in hospitalized elderly osteoporotic fracture patients

   Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·May 29, 2023

1. FRAX is associated with Re-fracture in humans (OR 2.9, 95% CI 1–8.2).

   “High fracture risk category (FRAX-H) was significantly associated with higher re-fracture”

   HumansHip fragility fracture patients; high fracture risk versus other FRAX categoriesOne year20 males, 74 femalessn = 94

   A combined fracture and mortality risk index useful for treatment stratification in hip fragility fractures

   Joint diseases and related surgery·Nov 19, 2021

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