bioRxiv
Some preleukemic cells suppress normal neighbors in culture
About 10% of preleukemic mutant clones actively suppressed or completely eliminated competing normal cells in a laboratory culture model.About 10% of preleukemic mutant clones actively suppressed or completely eliminated competing normal cells in a laboratory culture model.
Preprint: animal cell studyMechanisms
Who was studiedHematopoietic stem cells, against wild type cells
What changed~10% of TET2-mutant clones actively suppressed wild type cell expansion and, in some cases, completely eliminated wild type clones
The catchTested in laboratory dishes; interactions inside living bone marrow were not measured