Neuronal α-synuclein disease

Disease

1 paper studies it1 more mentions it2 findings

1 new paper in 30 daysSee all 2

Humans1

Associations

lysosome biogenesis

mixedin humans1

1 study

Neuronal α-synuclein disease is associated with lysosome biogenesis in humans.
“Lysosome biogenesis was the only reproducibly enriched pathway towards Stage 3.”
Humanstoward Stage 3cerebrospinal fluid
Spinal fluid protein patterns recur in early Parkinson’s
medRxivOct 20, 2026Preprint

Synaptic and neurosecretory protein signature

mixedin humans1

1 study

Neuronal α-synuclein disease is associated with synaptic and neurosecretory protein signature in humans.
“A reproducible set of synaptic and neurosecretory proteins separated controls from Stage 3 (RPH3A, STX1B, NRXN1, PALM, NPY).”
HumansStage 3 versus healthy controlscerebrospinal fluid
Spinal fluid protein patterns recur in early Parkinson’s
medRxivOct 20, 2026Preprint

More on Synaptic and neurosecretory protein signature

Latest

2 papers in 12 months

medRxivOct 20

Spinal fluid protein patterns recur in early Parkinson’s

The observational preprint compared healthy controls, people with possible early signs and people with untreated Parkinson’s in independent cohorts of 721 and 974…The observational preprint compared healthy controls, people with possible early signs and people with untreated Parkinson’s in independent cohorts of 721 and 974 participants.

Preprint: cross-sectional studyParkinson's disease

Paper

Research SquareSep 3

Pre-dementia clinical trajectories associated with neuronal α-synuclein neuropathologic change: a retrospective cohort study

Preprint: cohort study of 1,543 peopleDementia