Myeloid malignancy

Disease1 paper2 findings

Humans1

Associations

2

Complex karyotype

upin humans1

1 study

Myeloid malignancy is associated with complex karyotype in humans.
Humansduring malignant progression in ERCC6L2 disease
Intense TP53 pathway selection drives clonal evolution from bone marrow failure to leukemia in ERCC6L2 disease · medRxiv · 17 Sep 2026 · Preprint

Non-missense TP53 mutations

upin humans1

1 study

Myeloid malignancy is associated with non-missense TP53 mutations in humans.
Humansin patients with malignancy compared to bone marrow failure phase
Intense TP53 pathway selection drives clonal evolution from bone marrow failure to leukemia in ERCC6L2 disease · medRxiv · 17 Sep 2026 · Preprint

Non-missense TP53 mutations →

Trial sponsors

M.D. Anderson Cancer Center
2 trialsPhase 1/286 people
Jacqueline Garcia, MD
1 trialPhase 116 people

Latest

4

CancerHuman trial21 Sep

Oral vitamin C supplementation in patients with clonal cytopenia of undetermined significance or lower-risk myeloid malignancies: Results from EVITA, a phase 2 randomized, placebo-controlled trial

medRxivHumansPreprint17 Sep

Intense TP53 pathway selection drives clonal evolution from bone marrow failure to leukemia in ERCC6L2 disease

Bones and joints

European Journal of HaematologyHumans13 Sep

Serial VAF Kinetics Reveal Dynamic Clonal Evolution Associated With Progression in Clonal Cytopenia of Undetermined Significance

Frontiers in MedicineReview11 Sep

The proteomic architecture of clonal hematopoiesis: a systematic review of niche remodeling and multi-compartment predictors of malignant transformation

Extracellular matrix remodelling

GSA 2024 AbstractHumans1 Jan

FITNESS AND TIME OF MUTATION ACQUISITION A BETTER PREDICTOR OF OUTCOME IN CLONAL HEMOPOIESIS COMPARED TO CLONE SIZE