TP53-mutant clones

Biomarker1 paper1 finding

Humans1

Upstream

1

ERCC6L2

upin humans1

1 study

ERCC6L2 increases TP53-mutant clones in humans.
HumansERCC6L2 disease
Intense TP53 pathway selection drives clonal evolution from bone marrow failure to leukemia in ERCC6L2 disease · medRxiv · 17 Sep 2026 · Preprint

Funding

National Cancer InstituteUS$429.2k1 grant since 2026

SOMATIC EVOLUTION AND PRE-CANCER OF TP53 MUTANT CLONES
National Cancer InstituteBaylor College of MedicineUS$429.2k2026–2028

Latest

1

medRxivHumansPreprint17 Sep

Intense TP53 pathway selection drives clonal evolution from bone marrow failure to leukemia in ERCC6L2 disease

Bones and joints